Ring Chromosome 13 and Ambiguous Genitalia

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Ring Chromosome 13 and Ambiguous Genitalia

Ambiguous genitalia, known to be associated with sex chromosome disorders, may also be seen with autosomal chromosome anomalies. Herein, we report a case with ambiguous genitalia and ring chromosome 13. Ring chromosome 13 is a rare genetic anomaly in which the loss of genetic material determines the clinical spectrum.

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Ring chromosome 13 in an infant with ambiguous genitalia.

Ring chromosome is a rare chromosomal abnormality. We report a case of ring chromosome 13 associated with ambiguous genitalia. Karyotype is the important investigation in the evaluation of a case with ambiguous genitalia and chromosomal analysis should not be limited to only presence of X and Y chromosomes.

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Ambiguous genitalia and intersex.

Intersex disorders are rare congenital malformations with over 80% being diagnosed with congenital adrenal hyperplasia (CAH). It can be challenging to determine the correct gender at birth and a detailed understanding of the embryology and anatomy is crucial. The birth of a child with intersex is a true emergency situation and an immediate transfer to a medical center familiar with the diagnosi...

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Surgery for Female Ambiguous Genitalia

Historically, in female pseudohermaphrodites a staged procedure with early clitoral reduction and delayed vaginoplasty was often the treatment of choice. In recent years several authors have described 1-stage genitoplasty that is performed in the first year of life. The 1stage procedure for clitoroplasty and vaginal exteriorization is preferable for an optimal functional and cosmetic result. Be...

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Ambiguous Genitalia in the Newborn

Efficient and accurate evaluation of the newborn who has ambiguous genitalia is required to provide appropriate medical therapy and assuage parental anxiety. Genital ambiguity usually is due to virilization of genetic females or undervirilization of genetic males who have normal gonads. Congenital adrenal hyperplasia is the most common condition leading to inappropriate virilization in females....

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ژورنال

عنوان ژورنال: Journal of Clinical Research in Pediatric Endocrinology

سال: 2014

ISSN: 1308-5727

DOI: 10.4274/jcrpe.1194